Acute haemodynamic and hormonal effects of oral doxazosin in normal subjects

Haemodynamic and hormonal effects of doxazosin, a long-acting alpha 1-adrenoceptor antagonist (2 mg) were compared with placebo in six normal men. Doxazosin at 2 mg produced lower supine systolic blood pressure and plasma cortisol concentration than control at 4 h only, but these changes were not sustained. Both supine and standing pulse rate were increased by active drug after 6 h. In this acute study doxazosin did not affect plasma renin or aldosterone concentrations.