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Non-additive Effects in Genomic Selection.

Luis Varona1,2, Andres Legarra3, Miguel A Toro4

  • 1Departamento de Anatomía, Embriología y Genética Animal, Universidad de Zaragoza, Zaragoza, Spain.

Frontiers in Genetics
|March 22, 2018
PubMed
Summary
This summary is machine-generated.

Genomic selection in livestock now includes non-additive genetic effects for improved breeding value prediction and mating strategies. This review explores methods and applications for enhanced genetic gain and variation.

Keywords:
crossbreedingdominanceepistasisgenetic evaluationgenomic selection

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Area of Science:

  • Animal Genetics and Breeding
  • Quantitative Genetics
  • Genomic Selection

Background:

  • Genomic selection is standard for livestock genetic evaluation, primarily using additive Single Nucleotide Polymorphism (SNP) effects.
  • Non-additive genetic effects are increasingly recognized for their importance in improving prediction accuracy and genetic response.
  • Incorporating non-additive effects offers potential for refined mate allocation and breeding schemes.

Purpose of the Study:

  • To review methods for integrating non-additive genetic effects into genomic selection frameworks.
  • To explore the applications of non-additive effects in predicting performance, mate allocation, and breeding schemes.
  • To identify future research directions for standardizing non-additive effect inclusion in genomic selection.

Main Methods:

  • Literature review of existing methodologies for estimating and incorporating non-additive genetic effects.
  • Analysis of the impact of non-additive effects on breeding value prediction accuracy.
  • Discussion of practical applications in livestock breeding programs.

Main Results:

  • Non-additive effects can significantly enhance the accuracy of genomic predictions.
  • Methods exist for estimating dominance and epistasis, though less standardized than additive effects.
  • Applications include optimizing crossbreeding and purebred selection strategies.

Conclusions:

  • Integrating non-additive genetic effects into genomic selection offers substantial benefits for livestock breeding.
  • Further research is needed to standardize methods and facilitate widespread adoption.
  • Future work should focus on practical implementation for maximizing genetic gain and diversity.