Related Experiment Video
Updated: Feb 13, 2026

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
Published on: April 8, 2020
The effect of host structure on the selectivity and mechanism of supramolecular catalysis of Prins cyclizations
William M Hart-Cooper1, Chen Zhao1, Rebecca M Triano1
1Chemical Sciences Division , Lawrence Berkeley National Laboratory , Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: fdtoste@berkeley.edu ; Email: rbergman@berkeley.edu ;
Abstract:
The effect of host structure on the selectivity and mechanism of intramolecular Prins reactions is evaluated using K12Ga4L6 tetrahedral catalysts. The host structure was varied by modifying the structure of the chelating moieties and the size of the aromatic spacers. While variation in chelator substituents was generally observed to affect changes in rate but not selectivity, changing the host spacer afforded differences in efficiency and product diastereoselectivity. An extremely high number of turnovers (up to 840) was observed. Maximum rate accelerations were measured to be on the order of 105, which numbers among the largest magnitudes of transition state stabilization measured with a synthetic host-catalyst. Host/guest size effects were observed to play an important role in host-mediated enantioselectivity.
Related Concept Videos
Catalysis
Introduction to Mechanisms of Enzyme Catalysis
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization
Viral Structure
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
What is Natural Selection?

