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Updated: Feb 13, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

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Published on: January 5, 2017

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Nivolumab in squamous cell carcinoma of the head and neck

Pol Specenier1

  • 1a Department of Oncology , Antwerp University Hospital , Edegem , Belgium.

Expert Review of Anticancer Therapy
|March 22, 2018
PubMed
Abstract

Insights

Nivolumab offers a survival benefit for recurrent/metastatic head and neck squamous cell carcinoma after chemotherapy failure. This immunotherapy is now FDA-approved, improving outcomes compared to standard treatments.

Area of Science:

  • Oncology
  • Immunotherapy

Background:

  • Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) has a poor prognosis after first-line chemotherapy.
  • No single agent previously demonstrated survival benefit in second-line treatment for R/M HNSCC.

Purpose of the Study:

  • To review the role of nivolumab in treating R/M HNSCC.
  • To evaluate nivolumab's efficacy as a second-line treatment option.

Main Methods:

  • Comprehensive literature review on nivolumab in HNSCC.
  • Analysis of data from the CheckMate 141 trial.

Main Results:

  • Nivolumab demonstrated an overall survival benefit compared to standard chemotherapy (docetaxel, methotrexate, or cetuximab).
  • FDA approval granted for nivolumab in this patient population.

Conclusions:

  • Nivolumab represents a significant advancement in second-line treatment for R/M HNSCC.
  • Management of immune-related adverse events is crucial for patients receiving nivolumab.
Keywords:
Anti-PD1HNSCCadverse eventshead and neck cancermetastaticnivolumabpembrolizumabrecurrentsecond line

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