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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
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Updated: Feb 13, 2026

Interaction between Phonological and Semantic Processes in Visual Word Recognition using Electrophysiology
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Early L2 Spoken Word Recognition Combines Input-Based and Knowledge-Based Processing.

Seth Wiener1, Kiwako Ito2, Shari R Speer2

  • 1Department of Modern Languages, Carnegie Mellon University, USA.

Language and Speech
|March 22, 2018
PubMed
Summary

Second language learners rapidly use statistical patterns in tonal languages, even with varied speakers. Increased acoustic variability makes learners rely more on learned language patterns than the incoming sound signal.

Keywords:
Mandarin ChineseSpoken word recognitionlexical tonesecond language acquisitionspeaker variability

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Area of Science:

  • Psycholinguistics
  • Second Language Acquisition
  • Speech Perception

Background:

  • Investigates the interplay between statistical learning and acoustic signal reliance in L2 spoken word recognition.
  • Examines how early learners utilize segmental and suprasegmental cues and their frequencies in non-native word recognition.

Framework:

  • An artificial tonal language was developed with varying tone informativeness based on neighborhood density.
  • Stimuli mimicked Mandarin's uneven distribution of syllable+tone combinations, manipulating syllable frequency and tone co-occurrence probability.

Implementation:

  • English learners of Mandarin participated, with half trained on one speaker (low variability) and half on four speakers (high variability).
  • Behavioral (forced-choice judgments) and eye-tracking measures assessed the use of statistical regularities.

Implications:

  • Early L2 learners integrate statistical regularities and acoustic information for spoken word recognition, predicting based on co-occurrence distributions.
  • Higher acoustic variability (multi-speaker input) shifts reliance from the acoustic signal to learned statistical patterns of tone-syllable co-occurrences.