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Updated: Feb 13, 2026

Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Scarring At Donor Sites After Split-Thickness Skin Graft: A Prospective, Longitudinal, Randomized Trial
Matilda Karlsson1, Moustafa Elmasry, Ingrid Steinvall
1In the Department of Hand Surgery, Plastic Surgery, and Burns, at Linköping University, Sweden, Matilda Karlsson, RN, is a Registered Nurse; Moustafa Elmasry, MD, PhD, is a Plastic Surgeon; Ingrid Steinvall, PhD, is a Research Nurse and Specialist in Intensive Care; Folke Sjöberg, MD, PhD, is an Anesthesiologist and Professor; Pia Olofsson MD, PhD, is a Consulting Plastic Surgeon; and Johan Thorfinn, MD, PhD, is a Senior Consultant of Plastic Surgery. The authors have disclosed no financial relationships related to this article. Submitted May 26, 2017; accepted in revised form October 27, 2017.
Objective:
The aim of this study was to evaluate scarring at split-thickness skin graft donor sites 8 years after surgery.
Methods:
At surgery, 67 patients were randomized to hydrofiber, polyurethane foam, or porcine xenograft treatment. Scars were evaluated with the Patient and Observer Scar Assessment Scale.
Results:
Results showed significant differences in observed scar outcomes at donor sites, leaving the polyurethane foam-treated and the porcine xenograft-treated patients with the least satisfying scars. Multivariable regression analysis showed that the group treated with the xenografts had worse scores for overall opinion of the scar than did the other groups (P = .03), the most important factor being pigmentation. There was no correlation between duration of healing time and quality of the scar.
Conclusions:
There were significant differences among the groups, with the hydrofiber group being the most satisfied with the appearance of their scar.
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