Effects of Thickness on Corneal Biomechanical Properties Using Optical Coherence Elastography
Srilatha Vantipalli1, Jiasong Li2, Manmohan Singh2
1College of Optometry, University of Houston, Houston, Texas.
Summary
Corneal thickness significantly impacts biomechanical measurements. UV riboflavin cross-linking (CXL) effects on corneal stiffness can be misinterpreted if thickness changes are not accounted for, especially with hypertonic solutions.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Tissue Mechanics
Background:
- Corneal biomechanical properties are crucial for eye health and are influenced by intraocular pressure, tissue thickness, and material characteristics.
- Understanding these factors is vital for interpreting treatments like UV riboflavin cross-linking (CXL).
Purpose of the Study:
- To investigate the influence of corneal tissue thickness on measured biomechanical properties.
- To differentiate the effects of CXL treatment from changes in corneal thickness using optical coherence elastography.
Main Methods:
- Dynamic optical coherence elastography quantified tissue deformation in response to an air pulse.
- Ex vivo rabbit eyes were subjected to hydration changes (saline, dextran) and UV riboflavin cross-linking (isotonic and hypertonic).
- Central corneal thickness (CCT) and relaxation rates were measured before and after interventions.
Main Results:
- Corneal thickness showed a strong positive correlation (R=0.9) with relaxation rates.
- Isotonic CXL increased relaxation rates without altering CCT.
- Hypertonic CXL significantly decreased CCT and minimally affected relaxation rates.
Conclusions:
- Corneal thickness and stiffness are positively correlated.
- Isotonic CXL enhances corneal stiffness, indicated by increased relaxation rates.
- Hypertonic CXL can decrease corneal stiffness by reducing tissue thickness, potentially counteracting CXL-induced stiffening.
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