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Human Parechovirus Meningitis with Adverse Neurodevelopmental Outcome: A Case Report

Mylene C Berk1, Andrea H L Bruning2, Aleid G van Wassenaer-Leemhuis3

  • 1From the Department of Pediatric Infectious Diseases, Emma Children's Hospital.

The Pediatric Infectious Disease Journal
|March 22, 2018
PubMed

Insights

Human parechovirus infections can cause severe illness in children. This case highlights significant long-term neurodevelopmental issues following human parechovirus-3 meningitis in a young boy.

Area of Science:

  • Virology
  • Pediatrics
  • Neuroscience

Background:

  • Human parechovirus infections are typically mild in children.
  • Severe manifestations like neonatal sepsis and meningoencephalitis are increasingly noted.
  • Long-term consequences of these infections remain understudied.

Observation:

  • A 5-year-old boy developed severe meningitis due to human parechovirus-3.
  • The child experienced significant neurodevelopmental sequelae post-infection.

Findings:

  • This case demonstrates severe, long-term neurodevelopmental deficits after human parechovirus-3 meningitis.
  • It underscores the potential for severe neurological outcomes in young children.

Implications:

  • Highlights the need for further research into long-term effects of parechovirus infections.
  • Emphasizes the importance of recognizing severe presentations and potential sequelae in pediatric neurology.
  • Informs clinical awareness regarding neurodevelopmental monitoring after severe viral meningitis in children.

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