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Melanoma of the Face and Mohs Micrographic Surgery: Nationwide Mortality Data Analysis
Oleksandr Trofymenko1, Jeremy S Bordeaux2, Nathalie C Zeitouni3
1College of Medicine-Tucson, University of Arizona, Tucson, Arizona.
Background:
Although Mohs micrographic surgery (MMS), narrow margin excision (NME), and wide margin excision (WME) are commonly used to treat melanoma of the face, there is a paucity of data comparing mortality outcomes for each method.
Objective:
To determine the association between surgical method used to treat cutaneous melanoma of the face and patient survival.
Materials And Methods:
A retrospective review of Surveillance, Epidemiology, and End Results registries for patients diagnosed with melanoma of the face between 2003 and 2012 was conducted.
Results:
The authors query resulted in 43,443 records. Patients with melanoma were more likely to undergo NME (57.79%) than WME (27.86%) or MMS (14.36%). Overall 5-year risk of death was higher with WME (hazard ratio [HR], 1.11; 95% confidence interval [CI], 1.00-1.23; p = .043) and NME (HR, 1.10; 95% CI, 1.00-1.20; p = .046) relative to MMS after adjusting for patient demographics, residence socioeconomic factors, and tumor characteristics. No statistically significant difference in melanoma-specific mortality was found between different surgical methods on multivariate analysis.
Conclusion:
Patients with melanoma of the face treated with MMS had similar melanoma-specific mortality or overall survival outcome as patients treated by other surgical modalities.
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