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Perspectives on Neuroscience
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Perspectives on Neuroscience

Published on: July 31, 2007

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Anti-Angiogenics: Current Situation and Future Perspectives

Katja Zirlik, Justus Duyster

    Oncology Research and Treatment
    |March 22, 2018
    PubMed

    Insights

    Anti-angiogenic therapies targeting vascular endothelial growth factor (VEGF) are approved for cancers. However, their effectiveness varies, prompting a review of current VEGF-targeted drugs and future directions.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Pharmacology

    Background:

    • Angiogenesis, the formation of new blood vessels, is crucial for tumor growth.
    • Vascular Endothelial Growth Factor (VEGF) drives angiogenesis and is overexpressed in many cancers.
    • VEGF signaling blockade is a strategy for anti-angiogenic cancer therapy.

    Purpose of the Study:

    • To review FDA-approved anti-angiogenic antibodies and tyrosine kinase inhibitors targeting VEGF.
    • To summarize the progress and future directions of VEGF-targeted cancer therapy.

    Main Methods:

    • Review of current literature on VEGF-targeted therapies.
    • Analysis of FDA-approved anti-angiogenic drugs (antibodies and tyrosine kinase inhibitors).

    Main Results:

    • 11 anti-VEGF drugs are approved for advanced cancers, used alone or with other treatments.
    • VEGF inhibition shows variable efficacy across different cancer types.
    • Anti-angiogenic therapies often have limited impact on overall patient survival.

    Conclusions:

    • VEGF-targeted therapies represent a significant advancement in cancer treatment.
    • Further research is needed to overcome resistance and improve outcomes with anti-angiogenic drugs.
    • Future directions include optimizing combination therapies and exploring novel therapeutic strategies.
    Keywords:
    AngiogenesisAnti-angiogenicsMonoclonal antibodiesTyrosine kinase inhibitorsVEGF

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