Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunity in dilated cardiomyopathy.

S K Das, J T Cassidy, S A Huber

    Heart and Vessels. Supplement
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Viral infections may trigger autoimmune responses leading to chronic cardiomyopathy. Identifying specific viral antigens is key to understanding and potentially treating this heart condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A bibliometric analysis of the 50 most cited articles on acromioclavicular joint reconstruction.

    Musculoskeletal surgery·2025
    Same author

    YouTube provides poor information regarding anterior cruciate ligament injury and reconstruction.

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2017
    Same author

    Outcomes Following Combined Laparoscopic Burch Urethropexy at Time of Mesh Sling Removal: A Prospective Cohort Study.

    Journal of minimally invasive gynecology·2016
    Same author

    Direct Gel Chromatographic Characterization and Quantification of Marine Dissolved Organic Carbon Using High-Sensitivity DOC Detection.

    Environmental science & technology·2011
    Same author

    Coxsackievirus B3 induction of NFAT: requirement for myocarditis susceptibility.

    Virology·2008
    Same author

    Coxsackievirus B3-induced myocarditis: infection of females during the estrus phase of the ovarian cycle leads to activation of T regulatory cells.

    Virology·2008
    Same journal

    Angiographic characteristics of Takayasu arteritis.

    Heart and vessels. Supplement·1992
    Same journal

    Takayasu arteritis in Korean children: clinical report of seventy cases.

    Heart and vessels. Supplement·1992
    Same journal

    Immunopathogenesis of Takayasu arteritis.

    Heart and vessels. Supplement·1992
    Same journal

    HLA typing of Takayasu arteritis in Korea.

    Heart and vessels. Supplement·1992
    Same journal

    HLA-linked susceptibility and resistance to Takayasu arteritis.

    Heart and vessels. Supplement·1992
    Same journal

    Hereditary factors of Takayasu arteritis.

    Heart and vessels. Supplement·1992
    See all related articles

    Area of Science:

    • Immunology
    • Cardiology
    • Virology

    Background:

    • Abnormal immunologic parameters are observed in cardiomyopathy, but their causal link is unclear.
    • Viral infections, particularly myocarditis, are suspected to perpetuate chronic cardiomyopathy through immune mediation.
    • A defect in suppressor T lymphocytes could underlie the autoimmune basis of the disorder.

    Purpose of the Study:

    • To explore the immunopathogenesis of cardiomyopathy.
    • To investigate the role of viral infections and specific antigens in the development of cardiomyopathy.
    • To identify potential triggers for autoimmune responses in heart disease.

    Main Methods:

    • Review of existing studies on viral myocarditis and cardiomyopathy.
    • Analysis of immunologic mechanisms, including T-cell responses.

    Related Experiment Videos

  • Hypothesizing the role of specific antigens in disease initiation.

    • Main Results:

    • Studies in mice demonstrate a link between viral myocarditis and subsequent cardiomyopathy.
    • The precise trigger mechanism initiating cardiomyopathy remains elusive.
    • Altered viral or cardiac tissue antigens may act as "hidden antigens" eliciting cytotoxic T-cell responses.

    Conclusions:

    • Viral infections are implicated in the development of cardiomyopathy.
    • Identifying specific antigens is crucial for understanding the immunopathogenesis of human cardiomyopathy.
    • Further research into "hidden antigens" could resolve dilemmas in cardiomyopathy etiology.