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Aging without Dementia is Achievable: Current Evidence from Epidemiological Research
Chengxuan Qiu1,2, Laura Fratiglioni2,3
1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Journal of Alzheimer'S Disease : JAD
|March 23, 2018
Summary
Aging without dementia is achievable, even in extreme old age. Studies show dementia risk is modifiable through interventions promoting general health, vascular health, and cognitive reserve.
Area of Science:
- Gerontology
- Neurology
- Epidemiology
Background:
- Dementia incidence and prevalence increase with age, questioning if it's an inevitable aging outcome.
- Research explores whether aging without dementia is possible.
Purpose of the Study:
- To review epidemiological and neuropathological evidence on aging without dementia.
- To investigate factors influencing cognitive function in extreme old age.
Main Methods:
- Analysis of epidemiological studies on dementia rates in older populations.
- Review of clinico-neuropathological findings in centenarians and supercentenarians.
- Examination of trends in dementia incidence in Europe and North America.
Main Results:
- Dementia can be avoided even in extreme old age (centenarians/supercentenarians).
- Cognitive reserve and resilience may mitigate dementia despite brain pathology.
- Dementia incidence has declined in Europe and North America, indicating modifiable risk.
Conclusions:
- Aging without dementia is achievable.
- Interventions targeting general health, vascular health, and cognitive reserve can preserve cognitive function.
- Dementia risk in late life is modifiable.
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