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Modelling and Optimization of Polycaprolactone Ultrafine-Fibres Electrospinning Process Using Response Surface
Adhi Anindyajati1, Philip Boughton2, Andrew J Ruys3
1School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia. aani2456@uni.sydney.edu.au.
Materials (Basel, Switzerland)
|March 23, 2018
Summary
Optimizing electrospinning of polycaprolactone (PCL) fibers for acetabular labrum implants using response surface methodology (RSM) achieved desired elastic modulus and minimal fiber diameter. This method effectively models and optimizes complex production parameters for tissue engineering scaffolds.
Area of Science:
- Biomaterials Engineering
- Tissue Engineering
- Polymer Science
Background:
- Electrospun fibers mimic the extracellular matrix, making them promising for tissue engineering scaffolds.
- Developing high-quality scaffolds requires understanding complex relationships between production parameters and material properties.
Purpose of the Study:
- To apply response surface methodology (RSM) to optimize electrospinning parameters for polycaprolactone (PCL) fibrous scaffolds.
- To identify key parameters influencing fiber diameter and elastic modulus for acetabular labrum implants.
Main Methods:
- Response surface methodology (RSM) was employed to analyze electrospinning of polycaprolactone (PCL).
- Multivariate analysis modeled the relationships between production parameters (concentration, flow rate, temperature, collector speed) and scaffold properties (fiber diameter, elastic modulus).
Main Results:
- Solution concentration significantly affected fiber diameter.
- Elastic modulus was influenced by concentration, flow rate, temperature, collector rotation speed, and their interactions.
- Optimized settings (10% PCL, 4.5 mL/h, 45°C, 1500 RPM) yielded a 25 MPa elastic modulus with a minimal fiber diameter of 1.39 ± 0.20 µm.
Conclusions:
- RSM is an effective tool for optimizing multivariate production parameters in electrospinning.
- This study successfully optimized PCL scaffold production for acetabular labrum applications, achieving desired mechanical properties and fine fiber structure.
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