Related Experiment Video
Updated: Feb 13, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Skin metastasis as the first manifestation of lung carcinoma
Ali Koyuncuer1, Sedat Suat Cüzdan2, Eyüp Şenköy3
11 Department of Pathology, 175675 Hatay State Hospital, Hatay , Turkey.
Abstract:
Lung cancer is the most frequently diagnosed non-skin cancer and has a high mortality rate. Skin metastases that manifest as visceral malignancies are rare. Cutaneous metastasis from lung cancer has been observed in only 0.22%-12% of cases and is rarely the first manifestation of lung cancer. The histopathological features of metastases are occasionally difficult to distinguish from those of primary cutaneous tumors, despite the rigorous application of useful techniques, particularly immunohistochemistry. We report 3 asymptomatic cases of men who presented with solitary periumbilical, sacral, and scalp metastasis as the first manifestation of an underlying malignant lung tumor.
Related Concept Videos
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Lung Capacity
Acute Pancreatitis II: Clinical Manifestations and Management
Angina III: Clinical Manifestations and Assessment
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Aneurysm II: Clinical Manifestations and Diagnostic Studies

