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First-trimester irisin and fetuin-A concentration in predicting macrosomia
Monika Zbucka-Kretowska1, Mariusz Kuzmicki2, Beata Telejko3
1a Department of Reproduction and Gynecological Endocrinology , Medical University of Bialystok , Bialystok , Poland.
Summary
Maternal irisin levels in the first trimester can predict the risk of macrosomia, a condition of excessive birth weight. Higher irisin concentrations were associated with increased newborn weight, suggesting its potential as an early diagnostic biomarker.
Area of Science:
- Reproductive endocrinology
- Maternal-fetal medicine
- Biomarker discovery
Background:
- Macrosomia poses significant risks to both mother and infant.
- Early identification of macrosomia is crucial for timely intervention.
- First-trimester biomarkers offer a window for predicting fetal growth abnormalities.
Purpose of the Study:
- To evaluate the diagnostic utility of first-trimester adipokines and placental markers in predicting macrosomia.
- To identify potential early biomarkers for identifying pregnancies at risk of macrosomia.
Main Methods:
- Prospective study of 328 pregnant women from 11-13 weeks gestation.
- Serum analysis of pregnancy-associated plasma protein-A, free β-human chorionic gonadotropin, placental growth factor (PIGF), and adipokines.
- Comparison of biomarker levels between women delivering macrosomic infants (n=26) and normal weight neonates (n=34).
Main Results:
- Mothers of macrosomic infants had significantly higher PIGF and irisin levels, and lower fetuin-A levels.
- Maternal irisin concentration was a significant predictor of birth weight, explaining 14% of its variability.
- Irisin demonstrated good diagnostic performance for macrosomia prediction (AUC=0.818), with a sensitivity of 0.769 and specificity of 0.794 at a cut-off of 1725.4 ng/ml.
Conclusions:
- Maternal serum irisin in the first trimester may serve as a valuable early biomarker for predicting macrosomia.
- Further research is warranted to validate irisin's role in clinical practice for macrosomia risk assessment.
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