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Updated: Feb 13, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Treatment responses in multidrug-resistant tuberculosis in Germany
J Heyckendorf1, F van Leth2, K Avsar3
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, German Center for Infection Research (DZIF), Brunswick, International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany.
Optimal treatment for multi/extensively drug-resistant tuberculosis (M/XDR-TB) yields outcomes comparable to standard tuberculosis. This study found similar microbiological conversion rates and clinical responses in M/XDR-TB patients under ideal conditions.
Area of Science:
- Pulmonology
- Infectious Diseases
- Microbiology
Background:
- Recent advances have improved treatment outcomes for multi/extensively drug-resistant tuberculosis (M/XDR-TB).
- Optimal resource settings facilitate individualized therapy for M/XDR-TB patients.
Purpose of the Study:
- To compare treatment responses between M/XDR-TB and non-M/XDR-TB patients.
- To evaluate the efficacy of individualized M/XDR-TB treatment under optimal conditions.
Main Methods:
- Prospective enrollment of TB patients across five German hospitals (March 2013-March 2016).
- Individualized treatment based on drug susceptibility testing and current guidelines.
- Assessment of 2-month and 6-month sputum smear and culture conversion rates, alongside clinical and radiological scores.
Main Results:
- Similar microbiological conversion rates observed between M/XDR-TB and non-M/XDR-TB groups.
- No significant differences in clinical or radiological scores between groups up to 6 months.
- M/XDR-TB patients achieved comparable 6-month culture conversion rates.
Conclusions:
- Under optimal clinical conditions, M/XDR-TB patients demonstrate treatment outcomes similar to non-M/XDR-TB patients.
- Individualized therapy with novel diagnostics and diverse treatment options is key to achieving favorable M/XDR-TB outcomes.
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