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A computerised tomographic study in DSM-III affective disorders.

A Rossi, P Stratta, C Petruzzi

    Journal of Affective Disorders
    |May 1, 1987
    PubMed
    Summary
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    This study found no significant differences in ventricular brain ratio (VBR) between different depression types or patient groups. VBR showed a weak association with age at onset, but this was not consistently significant after controlling for current age.

    Area of Science:

    • Neuroimaging
    • Psychiatry
    • Clinical Psychology

    Background:

    • The ventricular brain ratio (VBR) is a measure of brain structure that has been explored in relation to various psychiatric conditions.
    • Previous research has investigated VBR in depression, but findings regarding its association with clinical variables have been inconsistent.

    Purpose of the Study:

    • To investigate the relationship between ventricular brain ratio (VBR) and specific clinical variables in patients diagnosed with depression according to DSM-III criteria.
    • To examine whether VBR differs across subtypes of depression, suicidal status, or gender.

    Main Methods:

    • The study included 21 patients diagnosed with DSM-III depression.
    • Ventricular brain ratio (VBR) was measured and analyzed in relation to clinical variables such as depression subtype, suicidal ideation, gender, and age at onset.

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  • A matched control group was used for comparison, with age controlled by decade.

    • Main Results:

    • No statistically significant differences in VBR were observed between major depression and dysthymic disorder, suicidal and non-suicidal patients, or male and female patients.
    • An association between VBR and age at onset of depression was found, but this failed to reach statistical significance when current age was controlled, except in the major depression subgroup.
    • When age was controlled by decade, no significant differences in VBR were found between depressed patients and a matched control group.

    Conclusions:

    • Ventricular brain ratio (VBR) does not appear to be a significant differentiating factor across major depression subtypes, suicidal status, or gender in this cohort.
    • The association between VBR and age at onset of depression is complex and may be influenced by current age, particularly in major depression.
    • Age-controlled comparisons suggest VBR is not significantly altered in depression compared to healthy controls.