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Convergent Spinal Circuits Facilitating Human Wrist Flexors.

Stefane A Aguiar1, Stuart N Baker2

  • 1Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 23, 2018
PubMed
Summary

We identified a new spinal circuit in humans that can be easily measured noninvasively. This circuit involves flexor motoneurons receiving input from both flexor and extensor pathways, aiding in upper limb control.

Keywords:
Golgi tendon organH-reflexIb pathwaysspinal circuitryspinal cord

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Area of Science:

  • Neuroscience
  • Human Physiology
  • Motor Control

Background:

  • Noninvasive assessment of human spinal circuitry, particularly Ib pathways in the upper limb, is challenging.
  • Understanding spinal reflex modulation is crucial for motor control and neurological condition assessment.

Purpose of the Study:

  • To develop and validate a noninvasive protocol for assessing a specific spinal circuit in healthy adults.
  • To investigate the afferent sources contributing to reflex facilitation in the upper limb.

Main Methods:

  • Evoked H-reflex in flexor carpi radialis (FCR) via median nerve stimulation.
  • Conditioned reflex using electrical stimulation of extensor carpi radialis (ECR) muscle.
  • Analyzed reflex modulation at different interstimulus intervals (ISIs).

Main Results:

  • Demonstrated significant reflex facilitation at a 30 ms ISI and suppression at a 70 ms ISI.
  • Results were consistent across all 18 healthy adult participants.
  • Provided evidence for convergent excitatory input onto flexor motoneurons from both FCR and ECR afferents.

Conclusions:

  • Established a novel, noninvasive method to assess a spinal circuit involving convergent inputs from flexor and extensor pathways.
  • This circuit can be readily assessed in humans, offering potential for clinical applications in neurological disorders.