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Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Chunyang Tian1, Jia Song1, Dongxu He1

  • 1Department of Cardiology, Shengjing Hospital of China Medical University.

International Heart Journal
|March 23, 2018
PubMed

Insights

The MPV/PC ratio is a superior predictor of long-term adverse outcomes in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI). This marker demonstrates better accuracy than MPV alone for predicting major adverse cardiovascular events.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Outcomes

Background:

  • Elevated mean platelet volume (MPV) is linked to poor outcomes in ST-segment elevation myocardial infarction (STEMI) patients post-percutaneous coronary intervention (PCI).
  • The prognostic value of the MPV/platelet count (MPV/PC) ratio in this patient group requires further investigation.

Purpose of the Study:

  • To evaluate the MPV/PC ratio as a predictor of long-term prognosis in STEMI patients undergoing PCI.
  • To compare the prognostic accuracy of the MPV/PC ratio against MPV alone.

Main Methods:

  • Analysis of 962 consecutive STEMI patients treated with primary PCI (P-PCI).
  • Patients were stratified into high (MPV/PC ≥ 0.055) and low (MPV/PC < 0.055) MPV/PC ratio groups.
  • Multivariate analysis and receiver-operating characteristic (ROC) curve analysis were employed.

Main Results:

  • High MPV/PC ratio independently predicted major adverse cardiovascular events (MACE), all-cause mortality, cardiac mortality, nonfatal myocardial reinfarction, and unplanned repeat revascularization.
  • The MPV/PC ratio showed good accuracy for MACE prediction (AUC: 0.764) with a cut-off of 0.054.
  • The MPV/PC ratio demonstrated superior discriminatory performance for MACE compared to MPV (P = 0.022).

Conclusions:

  • The MPV/PC ratio serves as a valuable and superior marker for predicting long-term adverse outcomes in STEMI patients undergoing P-PCI.
  • This ratio offers enhanced prognostic accuracy compared to MPV alone, aiding in risk stratification.

Keywords:
Long-term prognosisPrimary percutaneous coronary interventionST-segment elevation myocardial infarction

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