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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Structural Organization of the Human Body: An Overview01:18

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It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
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The Fluid Mosaic Model01:34

The Fluid Mosaic Model

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The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
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Fluid Pressure01:14

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In mechanical engineering, fluid pressure plays a critical role in designing systems that utilize liquid flow, such as hydraulic systems, pumps, and valves. When designing these systems, engineers must ensure they can withstand the forces created by fluid pressure to avoid damage or failure.
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Accelerating Fluids01:17

Accelerating Fluids

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When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
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Cerebrospinal Fluid01:21

Cerebrospinal Fluid

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Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
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Related Experiment Video

Updated: Feb 13, 2026

Isolation and Culture of Primary Human Gingival Epithelial Cells using Y-27632
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Human Gingival Crevicular Fluids (GCF) Proteomics: An Overview.

Zohaib Khurshid1, Maria Mali2, Mustafa Naseem3

  • 1Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia. drzohaibkhurshid@gmail.com.

Dentistry Journal
|March 23, 2018
PubMed
Summary

Gingival crevicular fluid (GCF) analysis using proteomics offers a non-invasive method for detecting periodontal diseases. This review explores GCF

Keywords:
biomarkersdentistrygingival crevicular fluids (GCFs)proteinsproteomics

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Area of Science:

  • Oral biology
  • Proteomics
  • Biomarker discovery

Background:

  • Gingival crevicular fluid (GCF) contains proteins, cells, and bacteria, reflecting periodontal health.
  • Proteomic tools enable detailed characterization of GCF components.
  • GCF analysis is a non-invasive approach for diagnostics.

Purpose of the Study:

  • To review the proteomic science of gingival crevicular fluids.
  • To discuss the physiology of GCF.
  • To highlight GCF's role in disease detection and drug analysis.

Main Methods:

  • Literature review of proteomic studies on GCF.
  • Analysis of GCF composition and its relation to periodontal status.
  • Exploration of GCF as a diagnostic fluid.

Main Results:

  • Proteomics has significantly advanced the characterization of GCF.
  • GCF serves as a valuable source for identifying biomarkers of periodontal disease.
  • Non-invasive sampling makes GCF ideal for ongoing research and clinical application.

Conclusions:

  • Proteomic analysis of GCF is a powerful tool for understanding periodontal health and disease.
  • GCF holds significant potential for early disease detection and therapeutic drug monitoring.
  • Further research into GCF proteomics can enhance diagnostic capabilities in dentistry.