Related Experiment Video

Updated: Feb 13, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.5K

nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

Ji-Hye Ahn1, Hyun-Sung Lee2, Ju-Seog Lee3

  • 1Department of Life and Nanopharmaceutical Sciences and Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, 02447, Korea.

Nature Communications
|March 23, 2018
PubMed

Insights

Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are key in cancer. This study reveals nc886 links these pathways in ovarian cancer, promoting malignancy and drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are crucial in cancer progression.
  • Elevated TGF-β signaling and suppressed miRNA expression characterize advanced ovarian cancer (OC), particularly the poor-prognosis fibrosis subtype.
  • The interaction between TGF-β and miRNA pathways in OC remains unclear.

Purpose of the Study:

  • To investigate the interplay between TGF-β signaling and miRNA regulation in ovarian cancer.
  • To elucidate the role of the non-coding RNA nc886 in OC pathogenesis.
  • To identify nc886 as a potential molecular link between TGF-β and miRNA pathways.

Main Methods:

  • Analysis of nc886 expression in OC patients.
  • Investigating the induction of nc886 by TGF-β.
  • Assessing the interaction of nc886 with Dicer to inhibit miRNA maturation.
  • Evaluating the impact of nc886 on OC cell behaviors like adhesion, migration, invasion, and drug resistance.

Main Results:

  • nc886 expression is induced by TGF-β in OC.
  • nc886 directly binds to Dicer, inhibiting miRNA maturation.
  • nc886 promotes OC cell adhesion, migration, invasion, and drug resistance.
  • High nc886 expression correlates with poor prognosis in OC patients.

Conclusions:

  • nc886 acts as a molecular bridge connecting the TGF-β and miRNA pathways in ovarian cancer.
  • nc886 contributes to the aggressive phenotype and drug resistance in OC by suppressing the miRNA pathway.
  • Targeting nc886 may offer a therapeutic strategy for ovarian cancer.

More Related Videos

Spheroid Assay to Measure TGF-β-induced Invasion09:18

Spheroid Assay to Measure TGF-β-induced Invasion

Published on: November 16, 2011

22.5K
Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System11:06

Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System

Published on: July 30, 2018

11.1K

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.1K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.0K
C4 Pathway and CAM01:27

C4 Pathway and CAM

Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
49.3K
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
4.2K