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Antidepressants and chronic pain.

J D Stauffer

    The Journal of Family Practice
    |August 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Antidepressants can effectively treat chronic pain syndromes when standard analgesics fail. Starting with low doses and gradually increasing them can manage pain and side effects, with results typically seen after three weeks.

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    Area of Science:

    • Pain Management
    • Neurology
    • Psychiatry

    Background:

    • Chronic pain syndromes present significant challenges in family medicine.
    • Standard analgesics often provide insufficient pain relief, necessitating alternative treatments.
    • Neurophysiological links exist between depression and chronic pain conditions.

    Purpose of the Study:

    • To review the neurophysiological similarities between depression and chronic pain.
    • To evaluate the efficacy of antidepressants in managing chronic pain syndromes.
    • To provide guidance on the use of antidepressants for pain management.

    Main Methods:

    • Review of neurophysiologic similarities between depression and chronic pain.
    • Analysis of double-blinded studies investigating antidepressant efficacy in chronic pain.

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  • Examination of dosage titration and side effect profiles.

    • Main Results:

    • Evidence supports the efficacy of antidepressants in treating chronic pain syndromes.
    • Antidepressants are a viable alternative when analgesics are inadequate.
    • Side effects are generally more tolerable at pain-management doses than antidepressive doses.

    Conclusions:

    • Antidepressants should be considered for chronic pain unresponsive to analgesics.
    • A stepwise dose increase is recommended, balancing efficacy and side effects.
    • Significant symptom relief typically requires at least three weeks of continuous therapy.