Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Down's syndrome. Precocious neurofilament antigen expression.

A V Plioplys

    Journal of the Neurological Sciences
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intravenous immunoglobulin treatment in autism.

    Journal of autism and developmental disorders·2000
    Same author

    A community-based study of chronic fatigue syndrome.

    Archives of internal medicine·1999
    Same author

    Chronic fatigue syndrome?

    Pediatrics·1999
    Same author

    Estimating the prevalence of chronic fatigue syndrome among nurses.

    The American journal of medicine·1998
    Same author

    Intravenous immunoglobulin treatment of children with autism.

    Journal of child neurology·1998
    Same author

    Survival rates among children with severe neurologic disabilities.

    Southern medical journal·1998
    Same journal

    Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

    Journal of the neurological sciences·2026
    Same journal

    Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

    Journal of the neurological sciences·2026
    Same journal

    Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

    Journal of the neurological sciences·2026
    Same journal

    Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

    Journal of the neurological sciences·2026
    Same journal

    Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

    Journal of the neurological sciences·2026
    Same journal

    Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

    Journal of the neurological sciences·2026
    See all related articles

    Neurofilament abnormalities are observed in Down syndrome (DS) brains, with early and widespread expression changes in axons. These alterations in neurofilament proteins may contribute to Alzheimer

    Area of Science:

    • Neurobiology
    • Neurodegenerative Diseases
    • Genetics

    Background:

    • Neuronal cytoskeletal abnormalities are implicated in various neurodevelopmental disorders, including Down syndrome (DS).
    • Neurofilaments, key components of the neuronal cytoskeleton, play a crucial role in axonal structure and function.

    Purpose of the Study:

    • To investigate neurofilament expression patterns in the central nervous system of individuals with Down syndrome.
    • To explore the potential link between altered neurofilament expression and the pathogenesis of Alzheimer's disease in DS.

    Main Methods:

    • Utilized MabN210 antibody, which targets the 210 kDa neurofilament subunit.
    • Applied immunohistochemical staining to autopsy-derived central nervous system tissue from DS and control subjects.
    • Examined cerebellar basket cell axons and central white matter tracts for neurofilament antigen expression and axonal caliber.

    Related Experiment Videos

    Main Results:

    • Observed precocious and aberrant neurofilament antigen expression in DS cerebellar basket cell axons during early infancy.
    • Detected an increased caliber of immunoreactive axons in central white matter tracts of DS brains, indicating widespread abnormalities.
    • Found abnormal regulation of neurofilament antigenic epitopes in DS neurons.

    Conclusions:

    • Down syndrome exhibits abnormal neurofilament expression, characterized by early and widespread changes in axonal components.
    • These neurofilament abnormalities in DS may be causally linked to the increased risk and development of Alzheimer's disease pathology.