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Development of controlled release silicone adhesive-based mupirocin patch demonstrates antibacterial activity on live

Sheba R David1, Nurafiqah Malek1, Abdul Hanif Mahadi2

  • 1PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam.

Drug Design, Development and Therapy
|March 23, 2018
PubMed
Abstract

Insights

This study developed a mupirocin patch to prevent Staphylococcus aureus peritonitis in peritoneal dialysis. The patch effectively reduced bacterial migration on rat skin, showing promise for infection control.

Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Drug Delivery Systems

Background:

  • Peritonitis, a severe complication of peritoneal dialysis, is often caused by Staphylococcus aureus.
  • S. aureus infections can necessitate a return to hemodialysis, highlighting the need for effective prevention strategies.

Purpose of the Study:

  • To develop a controlled-release silicone adhesive-based mupirocin patch for preventing S. aureus-related peritonitis.
  • To evaluate the antibacterial effectiveness of the mupirocin patch both in vitro and in vivo.

Main Methods:

  • Patches were formulated using various polymers and silicone adhesive, characterized for physical and chemical properties.
  • In vitro drug release and antibacterial activity (zone of inhibition) were assessed.
  • In vivo studies on rats evaluated bacterial counts, skin irritation, and histopathology.

Main Results:

  • The mupirocin patches exhibited suitable mechanical properties, high drug content (94.5-97.4%), and controlled release (47.94% at 8 hours).
  • Significant antibacterial activity was observed, with the highest zone of inhibition reaching 28.3 mm against S. aureus.
  • In vivo studies demonstrated reduced bacterial migration on rat skin and confirmed the patches were non-irritant and non-toxic.

Conclusions:

  • The developed mupirocin patch effectively reduced S. aureus migration on live rat skin.
  • Further long-term studies are needed to confirm efficacy in a peritonitis-induced animal model.
Keywords:
antibacterialdialysis infectionhistopathologymatrix patchperitonitistransdermal delivery

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