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Updated: Feb 13, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
Analysis of long range dependence in the EEG signals of Alzheimer patients
T Nimmy John1, Subha D Puthankattil1, Ramshekhar Menon2
11Department of Electrical Engineering, National Institute of Technology Calicut, Kozhikode, India.
Abstract:
Alzheimer's disease (AD), a cognitive disability is analysed using a long range dependence parameter, hurst exponent (HE), calculated based on the time domain analysis of the measured electrical activity of brain. The electroencephalogram (EEG) signals of controls and mild cognitive impairment (MCI)-AD patients are evaluated under normal resting and mental arithmetic conditions. Simultaneous low pass filtering and total variation denoising algorithm is employed for preprocessing. Larger values of HE observed in the right hemisphere of the brain for AD patients indicated a decrease in irregularity of the EEG signal under cognitive task conditions. Correlations between HE and the neuropsychological indices are analysed using bivariate correlation analysis. The observed reduction in the values of Auto mutual information and cross mutual information in the local antero-frontal and distant regions in the brain hemisphere indicates the loss of information transmission in MCI-AD patients.
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