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Updated: Feb 13, 2026

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
Published on: March 2, 2020
Roadblocks in the Path of iPSC to the Clinic
Elena Garreta1, Sonia Sanchez2, Jeronimo Lajara2
11Pluripotent stem cells and activation of endogenous tissue programs for organ regeneration (PR Lab), Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Purpose Of Review:
The goal of this paper is to highlight the major challenges in the translation of human pluripotent stem cells into a clinical setting.
Recent Findings:
Innate features from human induced pluripotent stem cells (hiPSCs) positioned these patient-specific cells as an unprecedented cell source for regenerative medicine applications. Immunogenicity of differentiated iPSCs requires more research towards the definition of common criteria for the evaluation of innate and host immune responses as well as in the generation of standardized protocols for iPSC generation and differentiation. The coming years will resolve ongoing clinical trials using both human embryonic stem cells (hESCs) and hiPSCs providing exciting information for the optimization of potential clinical applications of stem cell therapies.
Summary:
Rapid advances in the field of iPSCs generated high expectations in the field of regenerative medicine. Understanding therapeutic applications of iPSCs certainly needs further investigation on autologous/allogenic iPSC transplantation.
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