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Left ventricular hypertrophy in chronically hypertensive ponies.

K S Rugh, H E Garner, R F Sprouse

    Laboratory Animal Science
    |June 1, 1987
    PubMed
    Summary
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    Systemic arterial hypertension is linked to equine laminitis. Chronically hypertensive laminitic ponies showed significant left ventricular hypertrophy compared to normotensive ponies, indicating cardiac changes associated with this condition.

    Area of Science:

    • Veterinary Cardiology
    • Equine Medicine
    • Pathophysiology

    Background:

    • Equine laminitis is often linked to systemic arterial hypertension.
    • Understanding the cardiac implications of hypertension in laminitic horses is crucial.

    Purpose of the Study:

    • To investigate left ventricular hypertrophy in ponies with chronic hypertension and laminitis.
    • To compare cardiac morphology between hypertensive laminitic ponies and normotensive controls.

    Main Methods:

    • Postmortem examination of hearts from nine hypertensive laminitic ponies and nine normotensive ponies.
    • Measurement of heart weight, ventricular weights, and free wall thickness relative to body weight.
    • Statistical comparison of cardiac parameters between the two groups.

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    Main Results:

    • Hypertensive ponies had significantly larger hearts (7.77 g/kg BW vs. 5.67 g/kg BW).
    • Increased combined left ventricle and septum weight (4.99 g/kg BW vs. 3.67 g/kg BW) and left ventricular free wall weight (3.71 g/kg BW vs. 2.62 g/kg BW) were observed.
    • Mean left ventricular free wall thickness was significantly greater in hypertensive ponies (26.1 mm vs. 22.5 mm).

    Conclusions:

    • Left ventricular hypertrophy is a significant finding in ponies with laminitis-induced hypertension.
    • Hypertension associated with equine laminitis leads to measurable cardiac remodeling, specifically in the left ventricle.