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Related Experiment Videos

Beta endorphin levels in CSF during methadone maintenance.

T R Kosten, M J Kreek, C Swift

    Life Sciences
    |August 31, 1987
    PubMed
    Summary
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    Methadone maintenance patients show significantly higher cerebrospinal fluid (CSF) beta-endorphin levels compared to controls. Plasma beta-endorphin and cortisol levels did not differ, indicating a dissociation between central and peripheral levels.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Endocrinology

    Background:

    • Previous research indicated comparable plasma beta-endorphin levels in patients on methadone maintenance and controls.
    • Cerebrospinal fluid (CSF) peptide levels in methadone patients were similar to controls, but CSF beta-endorphin was not directly measured.

    Purpose of the Study:

    • To compare CSF and plasma beta-endorphin levels in patients on methadone maintenance with control subjects.
    • To investigate the relationship between CSF and plasma beta-endorphin and cortisol levels in this population.

    Main Methods:

    • Measured CSF and plasma beta-endorphin levels in 11 methadone-maintained patients (≥10 months) and 13 controls undergoing spinal anesthesia.
    • Analyzed plasma cortisol levels.
    • Used statistical analysis, including covariance for age, to compare groups and assess correlations.

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    Main Results:

    • CSF beta-endorphin levels were significantly higher in methadone patients (52.3 pg/ml) than controls (21.7 pg/ml).
    • Plasma beta-endorphin and cortisol levels did not differ between groups.
    • Plasma beta-endorphin correlated with plasma cortisol but not with CSF beta-endorphin levels.

    Conclusions:

    • Findings support previous studies on plasma beta-endorphin levels in methadone patients.
    • A novel dissociation was observed between central (CSF) and peripheral (plasma) beta-endorphin levels in methadone-maintained patients.