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Updated: Feb 12, 2026

Associated Chromosome Trap for Identifying Long-range DNA Interactions
Published on: April 23, 2011
Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Change Analysis in
Kevin Yauy1, Vincent Gatinois2, Thomas Guignard2
1Unit of Chromosomal Genetics, Department of Medical Genetics, Arnaud de Villeneuve Hospital, CHU Montpellier, Montpellier Cedex 5, France. k-yauy@chu-montpellier.fr.
Abstract:
Apparition of next-generation sequencing (NGS) was a breakthrough on knowledge of genome structure. Bioinformatic tools are a key point to analyze this huge amount of data from NGS and characterize the three-dimensional organization of chromosomes. This chapter describes usage of different browsers to explore publicly available online data and to search for possible 3D chromatin changes involved during complex chromosomal rearrangements as chromothripsis. Their pathogenic impact on clinical phenotype and gene misexpression can also be evaluated with annotated databases.
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