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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
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Hypertension

Suzanne Oparil1, Maria Czarina Acelajado2, George L Bakris3

  • 1Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, School of Medicine, The University of Alabama at Birmingham (UAB), 1720 2nd Avenue South, Birmingham, AL, 35294-0007, USA.

Nature Reviews. Disease Primers
|March 23, 2018
PubMed

Insights

Systemic arterial hypertension is a major global health risk. Effective management through lifestyle changes and medication significantly reduces cardiovascular disease (CVD) risks and mortality.

Area of Science:

  • Internal Medicine
  • Cardiology
  • Public Health

Background:

  • Systemic arterial hypertension is a leading modifiable risk factor for global morbidity and mortality.
  • Hypertension significantly increases the risk of cardiovascular disease (CVD), yet awareness and treatment rates remain suboptimal.
  • The development of hypertension stems from a complex interaction between environmental, pathophysiological, and genetic factors.

Purpose of the Study:

  • To outline the significance of hypertension as a public health issue.
  • To detail the comprehensive evaluation process for hypertensive patients.
  • To emphasize the importance of lifestyle modifications and pharmacological treatments in managing hypertension and preventing CVD.

Main Methods:

  • Standardized blood pressure (BP) measurement.
  • Assessment of atherosclerotic CVD risk and target-organ damage.
  • Screening for secondary causes of hypertension and comorbidities.
  • Evaluation of lifestyle interventions (diet, physical activity).
  • Review of first-line pharmacological therapies.

Main Results:

  • Successful hypertension treatment demonstrably reduces global disease burden and mortality.
  • Lifestyle modifications are effective in lowering BP and preventing hypertension-related CVD.
  • Pharmacological therapies, including ACE inhibitors, ARBs, CCBs, and thiazide diuretics, are highly effective in lowering BP and preventing CVD outcomes.

Conclusions:

  • Hypertension management is critical for reducing all-cause mortality and morbidity.
  • A multi-faceted approach combining lifestyle changes and pharmacotherapy is essential for effective hypertension control.
  • Early detection and adequate treatment of hypertension are key to mitigating its severe cardiovascular consequences.

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