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Phytochemicals in Skin Cancer Prevention and Treatment: An Updated Review

Chau Yee Ng1,2,3,4, Hsi Yen5,6,7, Hui-Yi Hsiao8

  • 1Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung 105, Taiwan. charlene870811@gmail.com.

International Journal of Molecular Sciences
|March 23, 2018
PubMed

Insights

Phytochemicals, plant-derived compounds, show promise for preventing and treating skin cancers due to their anti-cancer properties. Further research into these natural agents could lead to improved skin cancer care.

Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Skin cancer is a major health concern, necessitating safer and more effective treatments.
  • Current therapies for skin cancer have limitations, highlighting the need for novel strategies.
  • Phytochemicals offer a promising avenue for skin cancer chemoprevention and treatment.

Purpose of the Study:

  • To review the potential of phytochemicals in managing skin cancers.
  • To explore the preventive and therapeutic effects of phytochemicals.
  • To discuss the bioavailability and structure-activity relationships of phytochemicals for skin cancer.

Main Methods:

  • Literature review of scientific studies on phytochemicals and skin cancer.
  • Analysis of phytochemicals' anti-carcinogenic mechanisms.
  • Evaluation of structure-activity relationships and bioavailability.

Main Results:

  • Phytochemicals exhibit anti-oxidative, anti-inflammatory, anti-proliferative, and anti-angiogenic effects.
  • These compounds demonstrate preventive and therapeutic potential against skin cancers.
  • Bioavailability and structure-activity relationships are crucial for efficacy.

Conclusions:

  • Phytochemicals represent a cost-effective and well-tolerated strategy for skin cancer management.
  • Further research is warranted to develop novel oncostatic phytochemicals.
  • Understanding phytochemical mechanisms can enhance skin cancer care and prevention.
Keywords:
chemopreventionphytomedicineskin cancer

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