Related Experiment Video

Updated: Feb 12, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

19.0K

miR‑24 may be a negative regulator of menin in lung cancer

Yunhu Pan1, Hongmei Wang2, Debin Ma3

  • 1Department of Respiratory Medicine, No. 92 Hospital of PLA, Nanping, Fujian 341000, P.R. China.

Oncology Reports
|March 23, 2018
PubMed

Insights

MicroRNA-24 (miR-24) promotes lung cancer growth and metastasis by inhibiting the tumor suppressor menin. Targeting miR-24 may offer a new strategy for lung cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Lung cancer incidence is rising, necessitating novel therapeutic targets.
  • MicroRNAs (miRNAs) play crucial roles in tumor development.
  • Menin, a tumor suppressor, is downregulated in lung cancer.

Purpose of the Study:

  • To investigate the role of miR-24 in lung cancer progression.
  • To explore the relationship between miR-24, menin, and the SMAD3 pathway.
  • To provide a theoretical basis for targeted lung cancer therapy.

Main Methods:

  • Cellular biological behavior assessed using MTT and Transwell assays.
  • miR-24 expression levels analyzed in relation to menin.
  • SMAD3 pathway activity investigated in the context of miR-24 and menin.

Main Results:

  • miR-24 was found to inhibit menin expression in lung cancer cells.
  • miR-24 promoted lung cancer cell growth and metastasis.
  • miR-24 suppressed lung cancer cell apoptosis by targeting menin.
  • miR-24 affects the SMAD3 pathway activity by inhibiting menin.

Conclusions:

  • miR-24 acts as an oncogenic miRNA in lung cancer by targeting menin.
  • Inhibition of miR-24 may represent a potential therapeutic strategy for lung cancer.
  • The miR-24/menin axis influences the SMAD3 pathway, impacting lung cancer progression.

More Related Videos

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.6K
Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells16:55

Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells

Published on: October 26, 2011

20.9K

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Holter Monitor: 24-Hour Monitoring01:23

Holter Monitor: 24-Hour Monitoring

Holter monitoring is a continuous electrocardiography (ECG) recording that tracks the heart's electrical activity over an extended period, generally 24 to 48 hours. This noninvasive diagnostic tool detects irregular heart rhythms that may not be captured during a standard ECG performed in a clinical setting.DeviceThe Holter monitor is a portable, small device connected to several electrodes on the patient's chest. These electrodes detect the heart's electrical signals and transmit them to the...
2.8K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.3K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.9K