Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Morphogenesis02:19

Morphogenesis

30.5K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.5K
Autophagic Cell Death01:18

Autophagic Cell Death

4.6K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.6K
Overview of Cell Death01:30

Overview of Cell Death

10.2K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
10.2K
Hair Cells01:22

Hair Cells

45.3K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
45.3K
Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Plant Hormones01:56

Plant Hormones

27.7K
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.

Nature communications·2026
Same author

KGBN: Augmenting and optimizing logical gene regulatory networks using knowledge graphs.

bioRxiv : the preprint server for biology·2026
Same author

Cellular heterogeneity and therapeutic response profiling of human IDH + glioma stem cell cultures.

Scientific reports·2025
Same author

Digital twin models for predicting venetoclax and azacitidine-induced neutropenia in patients with acute myeloid leukemia.

NPJ digital medicine·2025
Same author

Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures.

bioRxiv : the preprint server for biology·2025
Same author

LM-Merger: a workflow for merging logical models with an application to gene regulatory network models.

BMC bioinformatics·2025
Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026
Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026
Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026
Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026
Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026
Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy
10:18

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

Published on: February 3, 2017

10.0K

Cell death as a trigger for morphogenesis.

Boris Aguilar1, Ahmadreza Ghaffarizadeh2, Christopher D Johnson2

  • 1Institute for Systems Biology, Seattle, WA, United States of America.

Plos One
|March 23, 2018
PubMed
Summary
This summary is machine-generated.

Biofilm wrinkling, a key survival mechanism, is triggered by localized cell death. This study models how biofilm material properties and cell death interactions drive this complex morphogenesis.

More Related Videos

A β-glucuronidase GUS Based Cell Death Assay
07:35

A β-glucuronidase GUS Based Cell Death Assay

Published on: May 6, 2011

28.8K
Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.6K

Related Experiment Videos

Last Updated: Feb 12, 2026

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy
10:18

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

Published on: February 3, 2017

10.0K
A β-glucuronidase GUS Based Cell Death Assay
07:35

A β-glucuronidase GUS Based Cell Death Assay

Published on: May 6, 2011

28.8K
Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.6K

Area of Science:

  • Microbiology
  • Biophysics
  • Computational Biology

Background:

  • Complex biofilm morphologies are crucial for microbial survival.
  • Wrinkle formation in biofilms is a key developmental process, potentially linked to cell death.
  • The biophysical mechanisms driving biofilm morphogenesis are not fully understood.

Purpose of the Study:

  • To investigate the hypothesis that biofilm material properties drive wrinkle formation in response to localized cell death.
  • To explore the relationship between cellular mechanical interactions and biofilm morphology changes.
  • To identify critical cellular interactions necessary for biofilm wrinkling.

Main Methods:

  • Utilized an agent-based model on the Biocellion high-performance platform.
  • Conducted computational simulations to reproduce biofilm wrinkle formation.
  • Analyzed cellular-level mechanical interactions and their impact on colony morphology.

Main Results:

  • Successfully modeled biofilm wrinkling driven by localized cell death.
  • Established quantitative relationships between cellular mechanics and morphological changes.
  • Identified key cellular interactions essential for wrinkle formation.

Conclusions:

  • Biofilm material properties play a significant role in powering and controlling wrinkle formation.
  • Computational modeling provides insights into the biophysical basis of biofilm development.
  • This work is a foundational step towards integrated experimental and computational models of biofilm morphogenesis.