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Mesenchymal stem cell therapy for paraquat poisoning: A systematic review and meta-analysis of preclinical studies

Fang He1, Aiting Zhou2, Shou Feng3

  • 1Key Laboratory of Cell Engineering of Guizhou Province, The Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, PR China.

Plos One
|March 23, 2018
PubMed
Abstract

Insights

Mesenchymal stem cells (MSCs) show promise in treating paraquat (PQ) poisoning by improving survival and reducing lung damage. This review of preclinical studies supports further research into MSC therapy for PQ poisoning.

Area of Science:

  • Regenerative Medicine
  • Toxicology
  • Cell Therapy

Background:

  • Paraquat (PQ) poisoning is a severe condition leading to multiple organ failure, with the lungs as the primary target.
  • Currently, no effective treatment exists for PQ poisoning.
  • Mesenchymal stem cells (MSCs) possess multipotent differentiation capabilities, making them a promising therapeutic candidate for various diseases.

Purpose of the Study:

  • To systematically review and analyze preclinical studies on MSC administration for PQ poisoning treatment in animal models.
  • To provide a scientific basis for the potential clinical application of cell therapy in PQ poisoning.

Main Methods:

  • A systematic review and meta-analysis of studies from PubMed and CBMdisc databases.
  • Evaluation of MSC treatment characteristics in animal models of PQ poisoning.
  • Assessment of MSC transplantation effects on survival rates, lung injury markers, oxidative stress, and inflammatory responses.

Main Results:

  • Eleven preclinical studies demonstrated that MSC therapy improved survival rates and reduced lung wet/dry weight and fibrosis in PQ-poisoned animals.
  • MSCs mitigated oxidative stress by altering malondialdehyde, superoxide dismutase, and glutathione levels.
  • MSC treatment led to decreased levels of pro-inflammatory cytokines (IL-1β, TNF-α) and fibrotic markers (TGF-β1, hydroxyproline).

Conclusions:

  • Mesenchymal stem cells exhibit anti-fibrotic effects in PQ-induced lung injury models, likely through the reduction of oxidative stress and inflammatory cytokines.
  • The findings support a potential therapeutic role for MSC therapy in treating paraquat poisoning.
  • This systematic review provides a rationale for advancing to clinical studies on MSCs for paraquat poisoning.

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