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Updated: Feb 12, 2026
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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
Published on: December 11, 2013
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Risk of major amputation in patients with intermittent claudication undergoing early revascularization
J Golledge1,2,3,4, J V Moxon1,2, S Rowbotham1,5,6
1Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.
The British Journal of Surgery
|March 23, 2018
Summary
Early revascularization for intermittent claudication may increase major amputation risk. Initial conservative treatment showed a significantly lower amputation rate in long-term outcomes for peripheral arterial disease patients.
Area of Science:
- Vascular Surgery
- Peripheral Arterial Disease
- Intermittent Claudication
Background:
- Revascularization is increasingly used for intermittent claudication.
- Long-term outcomes of revascularization for this condition are underreported.
Purpose of the Study:
- Compare long-term outcomes of revascularization versus conservative treatment for intermittent claudication.
- Evaluate major amputation rates in patients with peripheral arterial disease.
Main Methods:
- Prospective study of 456 patients with intermittent claudication and peripheral arterial disease.
- Comparison of early revascularization versus initial conservative treatment groups.
- Follow-up using linked hospital admission data; primary outcome: major amputation.
Main Results:
- 5-year major amputation rate was 6.2% for early revascularization vs. 0.7% for conservative treatment (P=0.003).
- Early revascularization was associated with a 4.22-5.40 times higher risk of major amputation.
- 456 patients recruited; 178 (39%) had early revascularization, 278 (61%) had conservative treatment.
Conclusions:
- Early revascularization for intermittent claudication appears to increase amputation risk compared to conservative management.
- Conservative treatment may be a safer initial approach for selected patients with peripheral arterial disease.
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