Related Experiment Video

Updated: Feb 12, 2026

Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

23.4K

Biomarkers of glomerular dysfunction in pre-eclampsia - A systematic review

Robert N Kerley1, Cathal McCarthy1

  • 1Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, Cork, Ireland.

Pregnancy Hypertension
|March 24, 2018
PubMed

Insights

Biomarkers of podocyte injury, such as urinary nephrin, show promise for diagnosing pre-eclampsia. Further large-scale studies are needed to confirm their clinical utility in routine antenatal care.

Area of Science:

  • Nephrology
  • Obstetrics
  • Biomarker Research

Background:

  • Early pre-eclampsia detection is crucial in antenatal care but often delayed due to non-specific symptoms.
  • Podocyte injury in pre-eclampsia leads to proteinuria, highlighting podocytes as key indicators.
  • This review focuses on the diagnostic potential of podocyte injury biomarkers.

Purpose of the Study:

  • To systematically review and assess the clinical utility of podocyte injury biomarkers for pre-eclampsia prediction.
  • To evaluate the diagnostic accuracy of identified biomarkers.

Main Methods:

  • A systematic literature review was conducted using QUADAS criteria.
  • The review focused on studies evaluating biomarkers of podocyte injury in pre-eclampsia.
  • Diagnostic accuracy data for identified biomarkers were pooled.

Main Results:

  • Five renal biomarkers were identified: podocytes, nephrin, synaptopodin, podocin, and podocalyxin.
  • The pooled sensitivity and specificity for all biomarkers were 0.78 and 0.82, respectively.
  • Urinary nephrin demonstrated the highest diagnostic accuracy with 0.81 sensitivity and 0.84 specificity.

Conclusions:

  • Glomerular injury biomarkers show potential as diagnostic aids for pre-eclampsia.
  • Urinary nephrin is a promising biomarker for pre-eclampsia diagnosis.
  • Large-scale prospective studies are required before routine clinical implementation.
Abstract

Keywords:
BiomarkersNephrinPodocytesPre-eclampsia

More Related Videos

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.8K
Assessment of Kidney Function in Mouse Models of Glomerular Disease09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.6K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Glomerular Filtration01:15

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
5.5K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.3K
pre-mRNA Processing02:01

pre-mRNA Processing

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
57.6K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.4K