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Updated: Feb 12, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Whole-brain volume alteration and its correlation with anxiety severity in patients with obsessive-compulsive
Gwang-Won Kim1, Woong Yoon2, Gwang-Woo Jeong2
1Advanced Institute of Aging Science, Chonnam National University, Gwangju, Republic of Korea.
Purpose:
To evaluate the differential gray matter (GM) and white matter volume alterations between healthy controls and patients with obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) using voxel-based morphometry (VBM).
Method:
Patients with OCD and GAD, and healthy controls underwent MR.
Results:
Patients with GAD showed significantly decreased GM volume in the medial prefrontal cortex (mPFC) compared with patients with OCD (p < 0.001). The GM volumes of the mPFC in patients with GAD were negatively correlated with Hamilton Anxiety Rating Scales.
Conclusion:
Our findings indicate that the mPFC volume abnormality may be associated with anxiety disorder in patients with GAD rather than OCD.
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