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Updated: Feb 12, 2026
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Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
Published on: December 17, 2019
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CAR T cell immunotherapy for human cancer
Carl H June1,2,3, Roddy S O'Connor4,2, Omkar U Kawalekar4
1Center for Cellular Immunotherapies, Perlman School of Medicine, Philadelphia, PA, USA. cjune@exchange.upenn.edu.
Science (New York, N.Y.)
|March 24, 2018
Summary
Adoptive T cell transfer (ACT) is revolutionizing cancer treatment. Chimeric antigen receptor (CAR) T cells show promise, but challenges remain for widespread use in oncology.
Area of Science:
- Immunotherapy
- Transfusion Medicine
- Oncology
Background:
- Adoptive T cell transfer (ACT) involves infusing lymphocytes for therapeutic effects.
- The field has progressed from preclinical immuno-oncology to approved CAR T cell therapies for leukemia and lymphoma.
Purpose of the Study:
- To review opportunities for CAR T cell therapy in mainstream oncology.
- To focus on challenges that have emerged in recent years for CAR T cell field.
Main Methods:
- Literature review of advancements in adoptive T cell transfer.
- Analysis of current challenges facing chimeric antigen receptor T cell therapy.
- Focus on recent developments in immuno-oncology.
Main Results:
- Chimeric antigen receptor (CAR) T cells have gained commercial approval for treating leukemia and lymphoma.
- Significant opportunities exist for CAR T cell therapy to enter mainstream oncology.
- Several challenges have emerged over the past few years impacting CAR T cell field.
Conclusions:
- CAR T cell therapy represents a significant advancement in immuno-oncology.
- Addressing current challenges is crucial for the broader integration of CAR T cells in cancer treatment.
- Continued research and development are essential for the future of ACT in oncology.
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