CAR T cell immunotherapy for human cancer
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Updated: Feb 12, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
Published on: December 17, 2019
Carl H June1,2,3, Roddy S O'Connor4,2, Omkar U Kawalekar4
1Center for Cellular Immunotherapies, Perlman School of Medicine, Philadelphia, PA, USA. cjune@exchange.upenn.edu.
Abstract:
Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with a focus on the challenges that have emerged over the past several years.
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