Related Experiment Video
Updated: Feb 12, 2026
09:19
Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma
Published on: July 14, 2022
4.3K
A perplexing primary novel hilar lesion: Remember the pneumonic PPNHL!
Ketaki Utpat1, Unnati D Desai1, Gayathri Amonkar2
1Department of Pulmonary Medicine, TNMC and BYL Nair Hospital, Mumbai, Maharashtra, India.
Indian Journal of Pathology & Microbiology
|March 24, 2018
Summary
Primary pulmonary non-Hodgkin's lymphoma (PPNHL) is a rare cause of hilar masses. This case highlights the diagnostic approach and preferred CHOP chemotherapy regimen for PPNHL.
Area of Science:
- Oncology
- Pulmonology
- Pathology
Background:
- Hilar masses can present with various symptoms including dyspnea, cough, and chest pain.
- Primary pulmonary non-Hodgkin's lymphoma (PPNHL) is an uncommon malignancy affecting the lungs.
- Accurate diagnosis of hilar masses requires a multimodal approach.
Observation:
- A 60-year-old female presented with symptoms suggestive of a left hilar mass.
- Diagnostic workup included clinicoradiological correlation, bronchoscopy, and computed tomography-guided biopsy.
- Histopathology and immunohistochemistry confirmed the diagnosis of PPNHL.
Findings:
- The case identified primary pulmonary non-Hodgkin's lymphoma (PPNHL) as the cause of the left hilar mass.
- Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common subtype of PPNHL.
- The study emphasizes the importance of integrating clinical, radiological, and pathological findings.
Implications:
- This case underscores the diagnostic challenges and considerations for evaluating hilar masses.
- Early and accurate diagnosis of PPNHL is crucial for effective treatment.
- The cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) chemotherapy regimen is a preferred treatment option for PPNHL.
Related Concept Videos
01:47Primary Active Transport
200.9K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
200.9K
01:29Primary Active Transport
14.5K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would...
14.5K
03:02Primary and Secondary Growth in Roots and Shoots
60.7K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.7K
01:06Primary Production
25.5K
The total amount of energy acquired by primary producers in an ecosystem is called gross primary production (GPP). However, of this energy, producers use some for metabolic processes, and some is lost as heat, decreasing the amount of energy available to the next trophic level. The remaining usable amount of energy is called the net primary productivity (NPP). In terrestrial ecosystems, NPP is driven by climate, while light penetration and nutrient availability drive NPP in aquatic ecosystems.
25.5K
01:28Primary Distribution
556
Primary distribution systems deliver electrical power from substations to consumers through various voltage classes, with 15-kV class voltages being predominant among U.S. utilities. Older 2.5- and 5-kV classes are being replaced by 15-kV primaries, while higher 25- to 34.5-kV classes are used in high-density urban areas and rural regions with long feeders. Three-phase, four-wire multigrounded systems are widely employed for balanced power delivery, using the neutral wire as a grounding point.
556
01:17Nomenclature of Primary Amines
4.6K
Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.
4.6K