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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Spindle cell sarcoma: a SEER population-based analysis.

Lei Feng1,2, Meng Wang1,2, Feiluore Yibulayin3,4

  • 1Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, China.

Scientific Reports
|March 24, 2018
PubMed
Summary
This summary is machine-generated.

Spindle cell sarcoma (SCS) primarily affects white individuals in their fifth to seventh decades. Patient age, AJCC stage, tumor location, and surgical treatment independently predict disease-specific survival and overall survival in SCS patients.

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Epidemiology

Background:

  • Spindle cell sarcoma (SCS) is a rare cancer with limited comprehensive population studies.
  • Understanding SCS clinical characteristics and prognostic factors is crucial for patient management.

Purpose of the Study:

  • To investigate the clinical characteristics of Spindle cell sarcoma (SCS).
  • To identify disease-specific prognostic factors influencing survival in SCS patients.

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) database (1973-2017).
  • Analyzed data from 3299 Spindle cell sarcoma (SCS) cases.
  • Employed multivariate Cox analysis to determine independent prognostic indicators.

Main Results:

  • SCS predominantly affects white individuals (79.1%) with a median age of 57, showing no gender predominance.
  • Significant differences in disease-specific survival (DSS) and overall survival (OS) were observed based on age, TNM stage, AJCC stage, tumor location, surgery, and pathologic grade.
  • Older age (>64 years), advanced AJCC stage (III), and non-surgical treatment were independently associated with worse DSS and OS.

Conclusions:

  • Spindle cell sarcoma (SCS) is most common in white individuals aged 50-70 without gender preference.
  • Age, AJCC stage, tumor location, and surgical intervention are independent prognostic indicators for both DSS and OS in SCS.
  • These findings highlight key factors for predicting outcomes in Spindle cell sarcoma (SCS) patients.