Related Experiment Video
Updated: Feb 12, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Exploiting rhodium-catalysed ynamide hydroacylation as a platform for divergent heterocycle synthesis
Robert N Straker1, Manjeet K Majhail1, Michael C Willis1
1Department of Chemistry , University of Oxford , Chemistry Research Laboratory , Mansfield Road , Oxford , OX1 3TA , UK .
Abstract:
The first examples of ynamide hydroacylation are described. Using rhodium catalysis, linear β-enaminone products are generated in high yield and excellent regioselectivity from the combination of aldehydes and ynamides. The enaminone products are subsequently used as a platform to construct a diverse array of substituted pyrazoles, pyrimidines, and isoxazoles in a two-step, one-pot sequence. It was found that with judicious choice of catalyst system it was possible to overturn the regioselectivity of the hydroacylation reaction to generate α-enaminone products.
Related Concept Videos
Divergence and Curl
Divergence and Stokes' Theorems
Gene Duplication and Divergence
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
Basicity of Heterocyclic Aromatic Amines
Transfer RNA Synthesis
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Nomenclature of Aryl and Heterocyclic Amines

