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Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: a case series

Nasser Shoeibi1,2, Seyedeh Maryam Hosseini1,2, Touka Banaee1,2

  • 11Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

International Journal of Retina and Vitreous
|March 24, 2018
PubMed

Insights

Intravitreal bevacizumab monotherapy for retinopathy of prematurity can cause thread-like vitreous condensation. This finding may predict further regression and retinal vascularization in infants.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Vascular Biology

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.
  • Anti-VEGF therapy, including intravitreal bevacizumab (IVB), is a common treatment for ROP.
  • Understanding treatment-related changes is crucial for patient management.

Purpose of the Study:

  • To report a specific clinical finding after IVB monotherapy for ROP.
  • To describe the characteristics and implications of vitreous changes observed post-IVB.

Main Methods:

  • Retrospective case series of five premature infants.
  • Single-dose intravitreal bevacizumab (IVB) monotherapy without laser therapy.
  • Observation of clinical course and vitreous changes.

Main Results:

  • Localized vitreous syneresis and linear fibrotic vitreous condensation observed 8.2 weeks post-IVB.
  • This finding occurred in 15.5% of injections.
  • All patients showed further regression and complete retinal vascularization.

Conclusions:

  • Thread-like vitreous condensation with liquefaction may be linked to involutional ROP and anti-VEGF therapy.
  • This vitreous change may predict further regression and retinal vascularization.
  • IVB monotherapy demonstrated a successful treatment response without complications.
Abstract

Keywords:
Anti-VEGFBevacizumabRetinopathy of prematurityVitreous condensationVitreous detachment

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