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Gestational trophoblastic neoplasm and women living with HIV and/or AIDS

Pieter Barnardt1, Martha Relling1

  • 1Department of Medical Imaging and Clinical Oncology, Division of Radiation Oncology, University of Stellenbosch, Tygerberg Campus, South Africa.

Southern African Journal of HIV Medicine
|March 24, 2018
PubMed

The 2011 World Health Organization global report on HIV and/or AIDS estimated that sub-Saharan Africa comprised 67% of the global HIV burden, with a current estimate of 5.9 million cases in South Africa. Since the introduction of antiretroviral therapy, there has been an increase in the incidence of non-AIDS-defining cancers. Gestational trophoblastic neoplasm (GTN) is a rare pregnancy-related disorder with an incidence ranging from 0.12-0.7/1000 pregnancies in Western nations. The overall cure rate is about 90%. Response to treatment for GTN is generally favourable; but the sequelae of HIV and/or AIDS, the resultant low CD4 counts, comorbidities, poor performance status and the extent of metastatic disease in patients receiving chemotherapy, compromise the prognosis and survival.

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