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Related Experiment Videos

Platelet function in acute respiratory failure.

A C Carvalho, D A Quinn, S M DeMarinis

    American Journal of Hematology
    |August 1, 1987
    PubMed
    Summary

    Platelet defects, including prolonged bleeding times and abnormal von Willebrand factor, occur in acute respiratory failure (ARF). These platelet alterations in ARF patients suggest in vivo activation and may contribute to complications.

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    Area of Science:

    • Hematology
    • Critical Care Medicine
    • Pulmonology

    Background:

    • Platelets play a crucial role in hemostasis and thrombosis.
    • Acute respiratory failure (ARF) is associated with significant morbidity and mortality, often involving thrombohemorrhagic complications.

    Purpose of the Study:

    • To investigate the role of platelets in the thrombohemorrhagic complications of ARF.
    • To assess platelet function and related markers in patients with ARF.

    Main Methods:

    • Studied platelet function in 13 ARF patients, 6 non-ARF intensive care patients, and 10 normal subjects.
    • Measured bleeding time, platelet aggregation (ADP, thrombin, epinephrine, collagen), and levels of von Willebrand factor (vWF:Ag, VIII:C, VIIIR:Ag), beta-thromboglobulin, platelet factor 4, thromboxane B2 (TXB2), and 6-keto-PGF1 alpha.

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    Main Results:

    • ARF patients exhibited prolonged bleeding times, unrelated to platelet count.
    • Impaired collagen-induced platelet aggregation and abnormal electrophoretic mobility of VIIIR:Ag were observed in ARF patients.
    • Elevated beta-thromboglobulin and significantly reduced 6-keto-PGF1 alpha levels were found in ARF patients, suggesting in vivo platelet activation.

    Conclusions:

    • ARF is associated with quantitative and qualitative platelet defects.
    • These platelet abnormalities, particularly related to von Willebrand factor and prostacyclin, may contribute to the thrombotic and hemorrhagic complications seen in ARF.
    • In vivo platelet activation occurs in patients with ARF.