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Antibiotic resistance patterns of urinary tract pathogens in Turkish children

Suzan Gunduz1, Hatice Uludağ Altun2

  • 1Department of Pediatrics, Private Batman Hospital, Gultepe mah. Palmiyem 1 sitesi D blok no: 13, Batman, Turkey.

Global Health Research and Policy
|March 24, 2018
PubMed

Insights

This study found Escherichia coli to be the most common cause of pediatric urinary tract infections. High resistance to ampicillin and co-trimoxazole necessitates careful antibiotic selection for effective treatment.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Resistance Surveillance
  • Clinical Microbiology

Background:

  • Understanding local antimicrobial resistance (AMR) patterns is crucial for effective empirical antibiotic prescribing in pediatric urinary tract infections (UTIs).
  • This study investigated the changing landscape of UTI pathogens and their resistance profiles in children within a specific healthcare setting.

Purpose of the Study:

  • To determine the primary causative agents of UTIs in children.
  • To analyze the antimicrobial resistance patterns of these pathogens.
  • To recommend optimal antibiotic choices for empirical treatment of pediatric UTIs.

Main Methods:

  • A retrospective analysis of urine isolates from positive cultures in children was conducted.
  • Data were collected from September 2014 to April 2016 at a single hospital in Ankara, Turkey.
  • Causative agents and their corresponding antimicrobial susceptibility were identified.

Main Results:

  • A total of 850 pediatric urine cultures were analyzed, with Escherichia coli (64.2%) being the predominant pathogen, followed by Klebsiella pneumoniae (14.9%).
  • Significant resistance was observed for ampicillin (62.6%), cephalothin (44.2%), co-trimoxazole (29.8%), and cefuroxime (28.7%).
  • Imipenem showed no resistance, while amikacin, ceftriaxone, ciprofloxacin, and cefepime exhibited low resistance rates.

Conclusions:

  • Escherichia coli is the leading cause of UTIs in the pediatric population studied.
  • High resistance rates to ampicillin, trimethoprim-sulfamethoxazole, cephalothin, and cefuroxime were noted.
  • Cefixime is suggested as a suitable oral empirical antibiotic choice, considering its activity against common pathogens including Klebsiella species.
Abstract

Keywords:
Empirical treatmentResistance patternsUrinary cultureUrinary tract infectionUropathogens

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