Related Experiment Video
Updated: Feb 12, 2026

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
Fractional flow reserve-CT assessment of coronary stenosis
Edmund K Kerut1,2, Michael Turner3
1Division of Cardiovascular Diseases, Department of Medicine, University of Mississippi School of Medicine, Jackson, MS, USA.
Abstract:
Coronary computed tomography angiography (CCTA) has been an established noninvasive method for detection of coronary artery disease (CAD). Although CCTA has had a high sensitivity and negative predictive value for CAD detection, specificity for obstructive CAD has been relatively low, partly due to coronary calcium, imaging artifacts, and other factors leading to an overestimation of stenosis severity. A relatively new noninvasive method of calculation of fractional flow reserve (FFR) using CCTA (FFRCT ) data has been developed. This noninvasive method yields similar results to invasive FFR measurement, improving specificity for noninvasively detecting lesion-specific ischemia thus helping guide revascularization.
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