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Risk factors for blood stream infections in multiple myeloma: A population-based study of 1154 patients in Denmark

Rasmus Sørrig1,2, Tobias W Klausen3, Morten Salomo1

  • 1Department of Hematology, Rigshospitalet, Copenhagen, Denmark.

European Journal of Haematology
|March 24, 2018
PubMed
Abstract

Insights

Multiple myeloma patients face high infection risks, particularly bloodstream infections (BSI). Aggressive disease presentation significantly increases BSI risk, often diagnosed alongside serious infections.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Epidemiology

Background:

  • Multiple myeloma (MM) patients exhibit a heightened susceptibility to infections.
  • Risk factors specifically for bloodstream infections (BSI) in this population remain underexplored.

Purpose of the Study:

  • To investigate the epidemiology of BSI in an unselected cohort of multiple myeloma patients.
  • To identify key risk factors associated with BSI development in MM patients.

Main Methods:

  • Utilized nationwide Danish data linking 1154 MM patients (2010-2013) with blood culture records (2010-2016).
  • Assessed the peak period for blood culture sampling and positive results for pathogenic microorganisms.

Main Results:

  • The highest frequency of blood cultures occurred between 30 days before and 180 days after MM diagnosis.
  • Risk factors for blood culture sampling in this period included immunoparesis, ISS-III, elevated creatinine, and high lactate dehydrogenase (LDH).
  • Factors associated with positive blood cultures during this peak period were ISS-III and high LDH.

Conclusions:

  • Multiple myeloma patients presenting with aggressive disease are at the greatest risk for BSI.
  • A significant proportion of MM diagnoses coincide with the initial presentation of a serious infection.
Keywords:
blood stream infectionsmultiple myelomarisk factors

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