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Range00:59

Range

14.4K
The range is one of the measures of variation. It can be defined as the difference between a dataset's highest and lowest values. For example, in the study of seven 16-ounce soda cans, the filled volume of soda was measured, thus producing the following amount (in ounces) of soda:
15.9; 16.1; 15.2; 14.8; 15.8; 15.9; 16.0; 15.5
Measurements of the amount of soda in a 16-ounce can vary since different subjects record these measurements or since the exact amount - 16 ounces of liquid, was not...
14.4K
Common Ion Effect03:24

Common Ion Effect

47.1K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
47.1K
Precipitation of Ions03:11

Precipitation of Ions

30.3K
Predicting Precipitation
The equation that describes the equilibrium between solid calcium carbonate and its solvated ions is:
30.3K
Ion Channels01:19

Ion Channels

91.5K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.5K
Leaky Scanning02:28

Leaky Scanning

5.7K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.7K
Formation of Complex Ions03:45

Formation of Complex Ions

26.2K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.2K

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Updated: Feb 12, 2026

Conducting Multiple Imaging Modes with One Fluorescence Microscope
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Macro-SICM: A Scanning Ion Conductance Microscope for Large-Range Imaging.

Nicolas Schierbaum, Martin Hack, Oliver Betz

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    A new Macro-Scanning Ion Conductance Microscope (Macro-SICM) significantly expands imaging range for delicate biological and material surfaces. This versatile tool enables high-resolution imaging across centimeter to micrometer scales, overcoming previous limitations.

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    Area of Science:

    • Materials Science
    • Biotechnology
    • Microscopy

    Background:

    • Scanning Ion Conductance Microscopy (SICM) offers high-resolution, noncontact imaging in liquid environments.
    • Conventional SICMs are limited by small lateral (100 μm) and vertical (10 μm) scan ranges.
    • Applications span chemistry, physics, and biology for delicate surface investigations.

    Purpose of the Study:

    • To develop a Scanning Ion Conductance Microscope (SICM) with an expanded scan range.
    • To demonstrate the versatility of the Macro-SICM across multiple length scales.
    • To apply the Macro-SICM to study collective cell migration in epithelial wound healing.

    Main Methods:

    • Development of a Macro-SICM with a 25 mm × 25 mm lateral and 0.25 mm vertical scan range.
    • Imaging of diverse samples including fingerprints, coins, tissue, insect wings, and cellular structures.
    • Application of Macro-SICM for observing collective cell migration dynamics.

    Main Results:

    • The Macro-SICM successfully imaged surfaces from centimeter down to micrometer scales.
    • Demonstrated versatility across various sample types and biological contexts.
    • Enabled detailed observation of collective cell migration in a wound healing model.

    Conclusions:

    • The Macro-SICM overcomes the scan range limitations of conventional SICMs.
    • This enhanced capability allows for versatile, multi-scale imaging of delicate structures.
    • The Macro-SICM is a powerful tool for biological research, including cell migration studies.