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An Isolable and Bench-Stable Epoxidizing Reagent Based on Triazine: Triazox
Kohei Yamada1, Yuki Igarashi1, Tatsuki Betsuyaku1
1Faculty of Pharmaceutical Sciences , Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University , Kakuma-machi, Kanazawa 920-1192 , Japan.
Abstract:
A new triazine-based oxidizing reagent, 2-hydroperoxy-4,6-diphenyl-1,3,5-triazine (Triazox), has been developed. The reagent can be synthesized from inexpensive starting materials and is a bench-stable solid that is isolable in pure form. Epoxidation of alkenes possessing acid-sensitive functionalities using Triazox proceeded in good to excellent yields. The accompanying nonacidic triazinone coproduct can be easily removed by filtration. These features indicate that Triazox is a practically useful oxidizing reagent.
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