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Strategies against methicillin-resistant Staphylococcus aureus persisters

Wooseong Kim1, Gabriel L Hendricks1, Katerina Tori1

  • 1Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

Future Medicinal Chemistry
|March 24, 2018
PubMed

Insights

New strategies combat chronic Staphylococcus aureus infections by targeting drug-resistant persister cells. These approaches aim to overcome antibiotic resistance and reduce infection relapses, improving treatment outcomes.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Chronic Staphylococcus aureus infections frequently relapse due to antibiotic resistance and the formation of dormant persister cells.
  • Persister cells evade conventional antibiotics by entering a metabolically inactive state, leading to high treatment failure rates.
  • Developing novel strategies against S. aureus persisters is crucial for effective infection control.

Purpose of the Study:

  • To review current strategies for identifying compounds active against Staphylococcus aureus persister cells.
  • To summarize proposed targets, antipersister compounds, and innovative methods to enhance antibiotic efficacy.
  • To categorize antipersister strategies for combating chronic S. aureus infections.

Main Methods:

  • Literature review of recent research on Staphylococcus aureus persister cells.
  • Analysis of proposed molecular targets and identified antipersister compounds.
  • Evaluation of innovative methods to potentiate existing antibiotics.

Main Results:

  • Identified two broad categories of antipersister strategies: targeting growth-independent pathways and enhancing antibiotic uptake/accessibility.
  • Summarized various compounds and methods aimed at eradicating persister cells.
  • Highlighted the potential of these strategies to overcome antibiotic resistance.

Conclusions:

  • Novel antipersister strategies show promise in overcoming challenges posed by Staphylococcus aureus persister cells.
  • Combining these strategies with conventional antibiotics may improve treatment outcomes for chronic infections.
  • Further research into growth-independent targets and antibiotic potentiation is warranted.
Keywords:
MRSAantibioticsdrug discoverpersisters

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